Terry 'Tee Tee' Twanisha of USA breasted the tape in 10.86 seconds to win the cutthroat women's 100m race at Kasarani.
The 4x100m relay world champion who was making her debut in the competition said the win has set her season in motion.
"It's amazing having won in Nairobi and I'll be heading back home for more preparations. The season has started and I will be taking meet-by-meet," Twanisha said in a post-race interview.
Zoe Hobbs of Newzealand was second in 10.97 and Rani Rosius of Belgium emerged in third place after clocking 11.08.
The category was won last season by double Olympic champion Shelly-Ann Fraser-Pryce of Jamaica. Fraser-Pryce suffered a knee injury on Friday ahead of the Saturday Kasarani showpiece.
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